  
                                  SEQUENCE LISTING
  
  <110> Government of the United States of America as represented by the
       Secretary of the Department of Health and Human Services National
       Institutes of Health
        Park, Sung Jun
        Kim, Myung Kyung
        Chung, Jay Hang
  
  <120> DNA-PKcs Modulates Energy Regulation and Brain Function
  
  <130> 1662.052WO1
  
  <150> US 60/958,714       
  <151> 2007-07-06  
  
  <160> 8
  
  <170> FastSEQ for Windows Version 4.0
  
  <210> 1
  <211> 4128
  <212> PRT
  <213> Homo sapiens
  
  <400> 1
  Met Ala Gly Ser Gly Ala Gly Val Arg Cys Ser Leu Leu Arg Leu Gln
   1               5                  10                  15      
  Glu Thr Leu Ser Ala Ala Asp Arg Cys Gly Ala Ala Leu Ala Gly His
              20                  25                  30          
  Gln Leu Ile Arg Gly Leu Gly Gln Glu Cys Val Leu Ser Ser Ser Pro
          35                  40                  45              
  Ala Val Leu Ala Leu Gln Thr Ser Leu Val Phe Ser Arg Asp Phe Gly
      50                  55                  60                  
  Leu Leu Val Phe Val Arg Lys Ser Leu Asn Ser Ile Glu Phe Arg Glu
  65                  70                  75                  80  
  Cys Arg Glu Glu Ile Leu Lys Phe Leu Cys Ile Phe Leu Glu Lys Met
                  85                  90                  95      
  Gly Gln Lys Ile Ala Pro Tyr Ser Val Glu Ile Lys Asn Thr Cys Thr
              100                 105                 110         
  Ser Val Tyr Thr Lys Asp Arg Ala Ala Lys Cys Lys Ile Pro Ala Leu
          115                 120                 125             
  
  Asp Leu Leu Ile Lys Leu Leu Gln Thr Phe Arg Ser Ser Arg Leu Met
      130                 135                 140                 
  Asp Glu Phe Lys Ile Gly Glu Leu Phe Ser Lys Phe Tyr Gly Glu Leu
  145                 150                 155                 160 
  Ala Leu Lys Lys Lys Ile Pro Asp Thr Val Leu Glu Lys Val Tyr Glu
                  165                 170                 175     
  Leu Leu Gly Leu Leu Gly Glu Val His Pro Ser Glu Met Ile Asn Asn
              180                 185                 190         
  Ala Glu Asn Leu Phe Arg Ala Phe Leu Gly Glu Leu Lys Thr Gln Met
          195                 200                 205             
  Thr Ser Ala Val Arg Glu Pro Lys Leu Pro Val Leu Ala Gly Cys Leu
      210                 215                 220                 
  Lys Gly Leu Ser Ser Leu Leu Cys Asn Phe Thr Lys Ser Met Glu Glu
  225                 230                 235                 240 
  Asp Pro Gln Thr Ser Arg Glu Ile Phe Asn Phe Val Leu Lys Ala Ile
                  245                 250                 255     
  Arg Pro Gln Ile Asp Leu Lys Arg Tyr Ala Val Pro Ser Ala Gly Leu
              260                 265                 270         
  Arg Leu Phe Ala Leu His Ala Ser Gln Phe Ser Thr Cys Leu Leu Asp
          275                 280                 285             
  Asn Tyr Val Ser Leu Phe Glu Val Leu Leu Lys Trp Cys Ala His Thr
      290                 295                 300                 
  Asn Val Glu Leu Lys Lys Ala Ala Leu Ser Ala Leu Glu Ser Phe Leu
  305                 310                 315                 320 
  Lys Gln Val Ser Asn Met Val Ala Lys Asn Ala Glu Met His Lys Asn
                  325                 330                 335     
  Lys Leu Gln Tyr Phe Met Glu Gln Phe Tyr Gly Ile Ile Arg Asn Val
              340                 345                 350         
  Asp Ser Asn Asn Lys Glu Leu Ser Ile Ala Ile Arg Gly Tyr Gly Leu
          355                 360                 365             
  Phe Ala Gly Pro Cys Lys Val Ile Asn Ala Lys Asp Val Asp Phe Met
      370                 375                 380                 
  Tyr Val Glu Leu Ile Gln Arg Cys Lys Gln Met Phe Leu Thr Gln Thr
  385                 390                 395                 400 
  Asp Thr Gly Asp Asp Arg Val Tyr Gln Met Pro Ser Phe Leu Gln Ser
                  405                 410                 415     
  Val Ala Ser Val Leu Leu Tyr Leu Asp Thr Val Pro Glu Val Tyr Thr
              420                 425                 430         
  Pro Val Leu Glu His Leu Val Val Met Gln Ile Asp Ser Phe Pro Gln
          435                 440                 445             
  Tyr Ser Pro Lys Met Gln Leu Val Cys Cys Arg Ala Ile Val Lys Val
      450                 455                 460                 
  Phe Leu Ala Leu Ala Ala Lys Gly Pro Val Leu Arg Asn Cys Ile Ser
  465                 470                 475                 480 
  Thr Val Val His Gln Gly Leu Ile Arg Ile Cys Ser Lys Pro Val Val
                  485                 490                 495     
  Leu Pro Lys Gly Pro Glu Ser Glu Ser Glu Asp His Arg Ala Ser Gly
              500                 505                 510         
  Glu Val Arg Thr Gly Lys Trp Lys Val Pro Thr Tyr Lys Asp Tyr Val
          515                 520                 525             
  Asp Leu Phe Arg His Leu Leu Ser Ser Asp Gln Met Met Asp Ser Ile
      530                 535                 540                 
  Leu Ala Asp Glu Ala Phe Phe Ser Val Asn Ser Ser Ser Glu Ser Leu
  545                 550                 555                 560 
  Asn His Leu Leu Tyr Asp Glu Phe Val Lys Ser Val Leu Lys Ile Val
                  565                 570                 575     
  Glu Lys Leu Asp Leu Thr Leu Glu Ile Gln Thr Val Gly Glu Gln Glu
              580                 585                 590         
  Asn Gly Asp Glu Ala Pro Gly Val Trp Met Ile Pro Thr Ser Asp Pro
          595                 600                 605             
  Ala Ala Asn Leu His Pro Ala Lys Pro Lys Asp Phe Ser Ala Phe Ile
      610                 615                 620                 
  Asn Leu Val Glu Phe Cys Arg Glu Ile Leu Pro Glu Lys Gln Ala Glu
  625                 630                 635                 640 
  Phe Phe Glu Pro Trp Val Tyr Ser Phe Ser Tyr Glu Leu Ile Leu Gln
                  645                 650                 655     
  Ser Thr Arg Leu Pro Leu Ile Ser Gly Phe Tyr Lys Leu Leu Ser Ile
              660                 665                 670         
  Thr Val Arg Asn Ala Lys Lys Ile Lys Tyr Phe Glu Gly Val Ser Pro
          675                 680                 685             
  Lys Ser Leu Lys His Ser Pro Glu Asp Pro Glu Lys Tyr Ser Cys Phe
      690                 695                 700                 
  Ala Leu Phe Val Lys Phe Gly Lys Glu Val Ala Val Lys Met Lys Gln
  705                 710                 715                 720 
  Tyr Lys Asp Glu Leu Leu Ala Ser Cys Leu Thr Phe Leu Leu Ser Leu
                  725                 730                 735     
  Pro His Asn Ile Ile Glu Leu Asp Val Arg Ala Tyr Val Pro Ala Leu
              740                 745                 750         
  Gln Met Ala Phe Lys Leu Gly Leu Ser Tyr Thr Pro Leu Ala Glu Val
          755                 760                 765             
  Gly Leu Asn Ala Leu Glu Glu Trp Ser Ile Tyr Ile Asp Arg His Val
      770                 775                 780                 
  Met Gln Pro Tyr Tyr Lys Asp Ile Leu Pro Cys Leu Asp Gly Tyr Leu
  785                 790                 795                 800 
  Lys Thr Ser Ala Leu Ser Asp Glu Thr Lys Asn Asn Trp Glu Val Ser
                  805                 810                 815     
  Ala Leu Ser Arg Ala Ala Gln Lys Gly Phe Asn Lys Val Val Leu Lys
              820                 825                 830         
  His Leu Lys Lys Thr Lys Asn Leu Ser Ser Asn Glu Ala Ile Ser Leu
          835                 840                 845             
  Glu Glu Ile Arg Ile Arg Val Val Gln Met Leu Gly Ser Leu Gly Gly
      850                 855                 860                 
  Gln Ile Asn Lys Asn Leu Leu Thr Val Thr Ser Ser Asp Glu Met Met
  865                 870                 875                 880 
  Lys Ser Tyr Val Ala Trp Asp Arg Glu Lys Arg Leu Ser Phe Ala Val
                  885                 890                 895     
  Pro Phe Arg Glu Met Lys Pro Val Ile Phe Leu Asp Val Phe Leu Pro
              900                 905                 910         
  Arg Val Thr Glu Leu Ala Leu Thr Ala Ser Asp Arg Gln Thr Lys Val
          915                 920                 925             
  Ala Ala Cys Glu Leu Leu His Ser Met Val Met Phe Met Leu Gly Lys
      930                 935                 940                 
  Ala Thr Gln Met Pro Glu Gly Gly Gln Gly Ala Pro Pro Met Tyr Gln
  945                 950                 955                 960 
  Leu Tyr Lys Arg Thr Phe Pro Val Leu Leu Arg Leu Ala Cys Asp Val
                  965                 970                 975     
  Asp Gln Val Thr Arg Gln Leu Tyr Glu Pro Leu Val Met Gln Leu Ile
              980                 985                 990         
  His Trp Phe Thr Asn Asn Lys Lys Phe Glu Ser Gln Asp Thr Val Ala
          995                 1000                1005            
  Leu Leu Glu Ala Ile Leu Asp Gly Ile Val Asp Pro Val Asp Ser Thr
      1010                1015                1020                
  Leu Arg Asp Phe Cys Gly Arg Cys Ile Arg Glu Phe Leu Lys Trp Ser
  1025                1030                1035                1040
  Ile Lys Gln Ile Thr Pro Gln Gln Gln Glu Lys Ser Pro Val Asn Thr
                  1045                1050                1055    
  Lys Ser Leu Phe Lys Arg Leu Tyr Ser Leu Ala Leu His Pro Asn Ala
              1060                1065                1070        
  Phe Lys Arg Leu Gly Ala Ser Leu Ala Phe Asn Asn Ile Tyr Arg Glu
          1075                1080                1085            
  Phe Arg Glu Glu Glu Ser Leu Val Glu Gln Phe Val Phe Glu Ala Leu
      1090                1095                1100                
  Val Ile Tyr Met Glu Ser Leu Ala Leu Ala His Ala Asp Glu Lys Ser
  1105                1110                1115                1120
  Leu Gly Thr Ile Gln Gln Cys Cys Asp Ala Ile Asp His Leu Cys Arg
                  1125                1130                1135    
  Ile Ile Glu Lys Lys His Val Ser Leu Asn Lys Ala Lys Lys Arg Arg
              1140                1145                1150        
  Leu Pro Arg Gly Phe Pro Pro Ser Ala Ser Leu Cys Leu Leu Asp Leu
          1155                1160                1165            
  Val Lys Trp Leu Leu Ala His Cys Gly Arg Pro Gln Thr Glu Cys Arg
      1170                1175                1180                
  His Lys Ser Ile Glu Leu Phe Tyr Lys Phe Val Pro Leu Leu Pro Gly
  1185                1190                1195                1200
  Asn Arg Ser Pro Asn Leu Trp Leu Lys Asp Val Leu Lys Glu Glu Gly
                  1205                1210                1215    
  Val Ser Phe Leu Ile Asn Thr Phe Glu Gly Gly Gly Cys Gly Gln Pro
              1220                1225                1230        
  Ser Gly Ile Leu Ala Gln Pro Thr Leu Leu Tyr Leu Arg Gly Pro Phe
          1235                1240                1245            
  Ser Leu Gln Ala Thr Leu Cys Trp Leu Asp Leu Leu Leu Ala Ala Leu
      1250                1255                1260                
  Glu Cys Tyr Asn Thr Phe Ile Gly Glu Arg Thr Val Gly Ala Leu Gln
  1265                1270                1275                1280
  Val Leu Gly Thr Glu Ala Gln Ser Ser Leu Leu Lys Ala Val Ala Phe
                  1285                1290                1295    
  Phe Leu Glu Ser Ile Ala Met His Asp Ile Ile Ala Ala Glu Lys Cys
              1300                1305                1310        
  Phe Gly Thr Gly Ala Ala Gly Asn Arg Thr Ser Pro Gln Glu Gly Glu
          1315                1320                1325            
  Arg Tyr Asn Tyr Ser Lys Cys Thr Val Val Val Arg Ile Met Glu Phe
      1330                1335                1340                
  Thr Thr Thr Leu Leu Asn Thr Ser Pro Glu Gly Trp Lys Leu Leu Lys
  1345                1350                1355                1360
  Lys Asp Leu Cys Asn Thr His Leu Met Arg Val Leu Val Gln Thr Leu
                  1365                1370                1375    
  Cys Glu Pro Ala Ser Ile Gly Phe Asn Ile Gly Asp Val Gln Val Met
              1380                1385                1390        
  Ala His Leu Pro Asp Val Cys Val Asn Leu Met Lys Ala Leu Lys Met
          1395                1400                1405            
  Ser Pro Tyr Lys Asp Ile Leu Glu Thr His Leu Arg Glu Lys Ile Thr
      1410                1415                1420                
  Ala Gln Ser Ile Glu Glu Leu Cys Ala Val Asn Leu Tyr Gly Pro Asp
  1425                1430                1435                1440
  Ala Gln Val Asp Arg Ser Arg Leu Ala Ala Val Val Ser Ala Cys Lys
                  1445                1450                1455    
  Gln Leu His Arg Ala Gly Leu Leu His Asn Ile Leu Pro Ser Gln Ser
              1460                1465                1470        
  Thr Asp Leu His His Ser Val Gly Thr Glu Leu Leu Ser Leu Val Tyr
          1475                1480                1485            
  Lys Gly Ile Ala Pro Gly Asp Glu Arg Gln Cys Leu Pro Ser Leu Asp
      1490                1495                1500                
  Leu Ser Cys Lys Gln Leu Ala Ser Gly Leu Leu Glu Leu Ala Phe Ala
  1505                1510                1515                1520
  Phe Gly Gly Leu Cys Glu Arg Leu Val Ser Leu Leu Leu Asn Pro Ala
                  1525                1530                1535    
  Val Leu Ser Thr Ala Ser Leu Gly Ser Ser Gln Gly Ser Val Ile His
              1540                1545                1550        
  Phe Ser His Gly Glu Tyr Phe Tyr Ser Leu Phe Ser Glu Thr Ile Asn
          1555                1560                1565            
  Thr Glu Leu Leu Lys Asn Leu Asp Leu Ala Val Leu Glu Leu Met Gln
      1570                1575                1580                
  Ser Ser Val Asp Asn Thr Lys Met Val Ser Ala Val Leu Asn Gly Met
  1585                1590                1595                1600
  Leu Asp Gln Ser Phe Arg Glu Arg Ala Asn Gln Lys His Gln Gly Leu
                  1605                1610                1615    
  Lys Leu Ala Thr Thr Ile Leu Gln His Trp Lys Lys Cys Asp Ser Trp
              1620                1625                1630        
  Trp Ala Lys Asp Ser Pro Leu Glu Thr Lys Met Ala Val Leu Ala Leu
          1635                1640                1645            
  Leu Ala Lys Ile Leu Gln Ile Asp Ser Ser Val Ser Phe Asn Thr Ser
      1650                1655                1660                
  His Gly Ser Phe Pro Glu Val Phe Thr Thr Tyr Ile Ser Leu Leu Ala
  1665                1670                1675                1680
  Asp Thr Lys Leu Asp Leu His Leu Lys Gly Gln Ala Val Thr Leu Leu
                  1685                1690                1695    
  Pro Phe Phe Thr Ser Leu Thr Gly Gly Ser Leu Glu Glu Leu Arg Arg
              1700                1705                1710        
  Val Leu Glu Gln Leu Ile Val Ala His Phe Pro Met Gln Ser Arg Glu
          1715                1720                1725            
  Phe Pro Pro Gly Thr Pro Arg Phe Asn Asn Tyr Val Asp Cys Met Lys
      1730                1735                1740                
  Lys Phe Leu Asp Ala Leu Glu Leu Ser Gln Ser Pro Met Leu Leu Glu
  1745                1750                1755                1760
  Leu Met Thr Glu Val Leu Cys Arg Glu Gln Gln His Val Met Glu Glu
                  1765                1770                1775    
  Leu Phe Gln Ser Ser Phe Arg Arg Ile Ala Arg Arg Gly Ser Cys Val
              1780                1785                1790        
  Thr Gln Val Gly Leu Leu Glu Ser Val Tyr Glu Met Phe Arg Lys Asp
          1795                1800                1805            
  Asp Pro Arg Leu Ser Phe Thr Arg Gln Ser Phe Val Asp Arg Ser Leu
      1810                1815                1820                
  Leu Thr Leu Leu Trp His Cys Ser Leu Asp Ala Leu Arg Glu Phe Phe
  1825                1830                1835                1840
  Ser Thr Ile Val Val Asp Ala Ile Asp Val Leu Lys Ser Arg Phe Thr
                  1845                1850                1855    
  Lys Leu Asn Glu Ser Thr Phe Asp Thr Gln Ile Thr Lys Lys Met Gly
              1860                1865                1870        
  Tyr Tyr Lys Ile Leu Asp Val Met Tyr Ser Arg Leu Pro Lys Asp Asp
          1875                1880                1885            
  Val His Ala Lys Glu Ser Lys Ile Asn Gln Val Phe His Gly Ser Cys
      1890                1895                1900                
  Ile Thr Glu Gly Asn Glu Leu Thr Lys Thr Leu Ile Lys Leu Cys Tyr
  1905                1910                1915                1920
  Asp Ala Phe Thr Glu Asn Met Ala Gly Glu Asn Gln Leu Leu Glu Arg
                  1925                1930                1935    
  Arg Arg Leu Tyr His Cys Ala Ala Tyr Asn Cys Ala Ile Ser Val Ile
              1940                1945                1950        
  Cys Cys Val Phe Asn Glu Leu Lys Phe Tyr Gln Gly Phe Leu Phe Ser
          1955                1960                1965            
  Glu Lys Pro Glu Lys Asn Leu Leu Ile Phe Glu Asn Leu Ile Asp Leu
      1970                1975                1980                
  Lys Arg Arg Tyr Asn Phe Pro Val Glu Val Glu Val Pro Met Glu Arg
  1985                1990                1995                2000
  Lys Lys Lys Tyr Ile Glu Ile Arg Lys Glu Ala Arg Glu Ala Ala Asn
                  2005                2010                2015    
  Gly Asp Ser Asp Gly Pro Ser Tyr Met Ser Ser Leu Ser Tyr Leu Ala
              2020                2025                2030        
  Asp Ser Thr Leu Ser Glu Glu Met Ser Gln Phe Asp Phe Ser Thr Gly
          2035                2040                2045            
  Val Gln Ser Tyr Ser Tyr Ser Ser Gln Asp Pro Arg Pro Ala Thr Gly
      2050                2055                2060                
  Arg Phe Arg Arg Arg Glu Gln Arg Asp Pro Thr Val His Asp Asp Val
  2065                2070                2075                2080
  Leu Glu Leu Glu Met Asp Glu Leu Asn Arg His Glu Cys Met Ala Pro
                  2085                2090                2095    
  Leu Thr Ala Leu Val Lys His Met His Arg Ser Leu Gly Pro Pro Gln
              2100                2105                2110        
  Gly Glu Glu Asp Ser Val Pro Arg Asp Leu Pro Ser Trp Met Lys Phe
          2115                2120                2125            
  Leu His Gly Lys Leu Gly Asn Pro Ile Val Pro Leu Asn Ile Arg Leu
      2130                2135                2140                
  Phe Leu Ala Lys Leu Val Ile Asn Thr Glu Glu Val Phe Arg Pro Tyr
  2145                2150                2155                2160
  Ala Lys His Trp Leu Ser Pro Leu Leu Gln Leu Ala Ala Ser Glu Asn
                  2165                2170                2175    
  Asn Gly Gly Glu Gly Ile His Tyr Met Val Val Glu Ile Val Ala Thr
              2180                2185                2190        
  Ile Leu Ser Trp Thr Gly Leu Ala Thr Pro Thr Gly Val Pro Lys Asp
          2195                2200                2205            
  Glu Val Leu Ala Asn Arg Leu Leu Asn Phe Leu Met Lys His Val Phe
      2210                2215                2220                
  His Pro Lys Arg Ala Val Phe Arg His Asn Leu Glu Ile Ile Lys Thr
  2225                2230                2235                2240
  Leu Val Glu Cys Trp Lys Asp Cys Leu Ser Ile Pro Tyr Arg Leu Ile
                  2245                2250                2255    
  Phe Glu Lys Phe Ser Gly Lys Asp Pro Asn Ser Lys Asp Asn Ser Val
              2260                2265                2270        
  Gly Ile Gln Leu Leu Gly Ile Val Met Ala Asn Asp Leu Pro Pro Tyr
          2275                2280                2285            
  Asp Pro Gln Cys Gly Ile Gln Ser Ser Glu Tyr Phe Gln Ala Leu Val
      2290                2295                2300                
  Asn Asn Met Ser Phe Val Arg Tyr Lys Glu Val Tyr Ala Ala Ala Ala
  2305                2310                2315                2320
  Glu Val Leu Gly Leu Ile Leu Arg Tyr Val Met Glu Arg Lys Asn Ile
                  2325                2330                2335    
  Leu Glu Glu Ser Leu Cys Glu Leu Val Ala Lys Gln Leu Lys Gln His
              2340                2345                2350        
  Gln Asn Thr Met Glu Asp Lys Phe Ile Val Cys Leu Asn Lys Val Thr
          2355                2360                2365            
  Lys Ser Phe Pro Pro Leu Ala Asp Arg Phe Met Asn Ala Val Phe Phe
      2370                2375                2380                
  Leu Leu Pro Lys Phe His Gly Val Leu Lys Thr Leu Cys Leu Glu Val
  2385                2390                2395                2400
  Val Leu Cys Arg Val Glu Gly Met Thr Glu Leu Tyr Phe Gln Leu Lys
                  2405                2410                2415    
  Ser Lys Asp Phe Val Gln Val Met Arg His Arg Asp Asp Glu Arg Gln
              2420                2425                2430        
  Lys Val Cys Leu Asp Ile Ile Tyr Lys Met Met Pro Lys Leu Lys Pro
          2435                2440                2445            
  Val Glu Leu Arg Glu Leu Leu Asn Pro Val Val Glu Phe Val Ser His
      2450                2455                2460                
  Pro Ser Thr Thr Cys Arg Glu Gln Met Tyr Asn Ile Leu Met Trp Ile
  2465                2470                2475                2480
  His Asp Asn Tyr Arg Asp Pro Glu Ser Glu Thr Asp Asn Asp Ser Gln
                  2485                2490                2495    
  Glu Ile Phe Lys Leu Ala Lys Asp Val Leu Ile Gln Gly Leu Ile Asp
              2500                2505                2510        
  Glu Asn Pro Gly Leu Gln Leu Ile Ile Arg Asn Phe Trp Ser His Glu
          2515                2520                2525            
  Thr Arg Leu Pro Ser Asn Thr Leu Asp Arg Leu Leu Ala Leu Asn Ser
      2530                2535                2540                
  Leu Tyr Ser Pro Lys Ile Glu Val His Phe Leu Ser Leu Ala Thr Asn
  2545                2550                2555                2560
  Phe Leu Leu Glu Met Thr Ser Met Ser Pro Asp Tyr Pro Asn Pro Met
                  2565                2570                2575    
  Phe Glu His Pro Leu Ser Glu Cys Glu Phe Gln Glu Tyr Thr Ile Asp
              2580                2585                2590        
  Ser Asp Trp Arg Phe Arg Ser Thr Val Leu Thr Pro Met Phe Val Glu
          2595                2600                2605            
  Thr Gln Ala Ser Gln Gly Thr Leu Gln Thr Arg Thr Gln Glu Gly Ser
      2610                2615                2620                
  Leu Ser Ala Arg Trp Pro Val Ala Gly Gln Ile Arg Ala Thr Gln Gln
  2625                2630                2635                2640
  Gln His Asp Phe Thr Leu Thr Gln Thr Ala Asp Gly Arg Ser Ser Phe
                  2645                2650                2655    
  Asp Trp Leu Thr Gly Ser Ser Thr Asp Pro Leu Val Asp His Thr Ser
              2660                2665                2670        
  Pro Ser Ser Asp Ser Leu Leu Phe Ala His Lys Arg Ser Glu Arg Leu
          2675                2680                2685            
  Gln Arg Ala Pro Leu Lys Ser Val Gly Pro Asp Phe Gly Lys Lys Arg
      2690                2695                2700                
  Leu Gly Leu Pro Gly Asp Glu Val Asp Asn Lys Val Lys Gly Ala Ala
  2705                2710                2715                2720
  Gly Arg Thr Asp Leu Leu Arg Leu Arg Arg Arg Phe Met Arg Asp Gln
                  2725                2730                2735    
  Glu Lys Leu Ser Leu Met Tyr Ala Arg Lys Gly Val Ala Glu Gln Lys
              2740                2745                2750        
  Arg Glu Lys Glu Ile Lys Ser Glu Leu Lys Met Lys Gln Asp Ala Gln
          2755                2760                2765            
  Val Val Leu Tyr Arg Ser Tyr Arg His Gly Asp Leu Pro Asp Ile Gln
      2770                2775                2780                
  Ile Lys His Ser Ser Leu Ile Thr Pro Leu Gln Ala Val Ala Gln Arg
  2785                2790                2795                2800
  Asp Pro Ile Ile Ala Lys Gln Leu Phe Ser Ser Leu Phe Ser Gly Ile
                  2805                2810                2815    
  Leu Lys Glu Met Asp Lys Phe Lys Thr Leu Ser Glu Lys Asn Asn Ile
              2820                2825                2830        
  Thr Gln Lys Leu Leu Gln Asp Phe Asn Arg Phe Leu Asn Thr Thr Phe
          2835                2840                2845            
  Ser Phe Phe Pro Pro Phe Val Ser Cys Ile Gln Asp Ile Ser Cys Gln
      2850                2855                2860                
  His Ala Ala Leu Leu Ser Leu Asp Pro Ala Ala Val Ser Ala Gly Cys
  2865                2870                2875                2880
  Leu Ala Ser Leu Gln Gln Pro Val Gly Ile Arg Leu Leu Glu Glu Ala
                  2885                2890                2895    
  Leu Leu Arg Leu Leu Pro Ala Glu Leu Pro Ala Lys Arg Val Arg Gly
              2900                2905                2910        
  Lys Ala Arg Leu Pro Pro Asp Val Leu Arg Trp Val Glu Leu Ala Lys
          2915                2920                2925            
  Leu Tyr Arg Ser Ile Gly Glu Tyr Asp Val Leu Arg Gly Ile Phe Thr
      2930                2935                2940                
  Ser Glu Ile Gly Thr Lys Gln Ile Thr Gln Ser Ala Leu Leu Ala Glu
  2945                2950                2955                2960
  Ala Arg Ser Asp Tyr Ser Glu Ala Ala Lys Gln Tyr Asp Glu Ala Leu
                  2965                2970                2975    
  Asn Lys Gln Asp Trp Val Asp Gly Glu Pro Thr Glu Ala Glu Lys Asp
              2980                2985                2990        
  Phe Trp Glu Leu Ala Ser Leu Asp Cys Tyr Asn His Leu Ala Glu Trp
          2995                3000                3005            
  Lys Ser Leu Glu Tyr Cys Ser Thr Ala Ser Ile Asp Ser Glu Asn Pro
      3010                3015                3020                
  Pro Asp Leu Asn Lys Ile Trp Ser Glu Pro Phe Tyr Gln Glu Thr Tyr
  3025                3030                3035                3040
  Leu Pro Tyr Met Ile Arg Ser Lys Leu Lys Leu Leu Leu Gln Gly Glu
                  3045                3050                3055    
  Ala Asp Gln Ser Leu Leu Thr Phe Ile Asp Lys Ala Met His Gly Glu
              3060                3065                3070        
  Leu Gln Lys Ala Ile Leu Glu Leu His Tyr Ser Gln Glu Leu Ser Leu
          3075                3080                3085            
  Leu Tyr Leu Leu Gln Asp Asp Val Asp Arg Ala Lys Tyr Tyr Ile Gln
      3090                3095                3100                
  Asn Gly Ile Gln Ser Phe Met Gln Asn Tyr Ser Ser Ile Asp Val Leu
  3105                3110                3115                3120
  Leu His Gln Ser Arg Leu Thr Lys Leu Gln Ser Val Gln Ala Leu Thr
                  3125                3130                3135    
  Glu Ile Gln Glu Phe Ile Ser Phe Ile Ser Lys Gln Gly Asn Leu Ser
              3140                3145                3150        
  Ser Gln Val Pro Leu Lys Arg Leu Leu Asn Thr Trp Thr Asn Arg Tyr
          3155                3160                3165            
  Pro Asp Ala Lys Met Asp Pro Met Asn Ile Trp Asp Asp Ile Ile Thr
      3170                3175                3180                
  Asn Arg Cys Phe Phe Leu Ser Lys Ile Glu Glu Lys Leu Thr Pro Leu
  3185                3190                3195                3200
  Pro Glu Asp Asn Ser Met Asn Val Asp Gln Asp Gly Asp Pro Ser Asp
                  3205                3210                3215    
  Arg Met Glu Val Gln Glu Gln Glu Glu Asp Ile Ser Ser Leu Ile Arg
              3220                3225                3230        
  Ser Cys Lys Phe Ser Met Lys Met Lys Met Ile Asp Ser Ala Arg Lys
          3235                3240                3245            
  Gln Asn Asn Phe Ser Leu Ala Met Lys Leu Leu Lys Glu Leu His Lys
      3250                3255                3260                
  Glu Ser Lys Thr Arg Asp Asp Trp Leu Val Ser Trp Val Gln Ser Tyr
  3265                3270                3275                3280
  Cys Arg Leu Ser His Cys Arg Ser Arg Ser Gln Gly Cys Ser Glu Gln
                  3285                3290                3295    
  Val Leu Thr Val Leu Lys Thr Val Ser Leu Leu Asp Glu Asn Asn Val
              3300                3305                3310        
  Ser Ser Tyr Leu Ser Lys Asn Ile Leu Ala Phe Arg Asp Gln Asn Ile
          3315                3320                3325            
  Leu Leu Gly Thr Thr Tyr Arg Ile Ile Ala Asn Ala Leu Ser Ser Glu
      3330                3335                3340                
  Pro Ala Cys Leu Ala Glu Ile Glu Glu Asp Lys Ala Arg Arg Ile Leu
  3345                3350                3355                3360
  Glu Leu Ser Gly Ser Ser Ser Glu Asp Ser Glu Lys Val Ile Ala Gly
                  3365                3370                3375    
  Leu Tyr Gln Arg Ala Phe Gln His Leu Ser Glu Ala Val Gln Ala Ala
              3380                3385                3390        
  Glu Glu Glu Ala Gln Pro Pro Ser Trp Ser Cys Gly Pro Ala Ala Gly
          3395                3400                3405            
  Val Ile Asp Ala Tyr Met Thr Leu Ala Asp Phe Cys Asp Gln Gln Leu
      3410                3415                3420                
  Arg Lys Glu Glu Glu Asn Ala Ser Val Ile Asp Ser Ala Glu Leu Gln
  3425                3430                3435                3440
  Ala Tyr Pro Ala Leu Val Val Glu Lys Met Leu Lys Ala Leu Lys Leu
                  3445                3450                3455    
  Asn Ser Asn Glu Ala Arg Leu Lys Phe Pro Arg Leu Leu Gln Ile Ile
              3460                3465                3470        
  Glu Arg Tyr Pro Glu Glu Thr Leu Ser Leu Met Thr Lys Glu Ile Ser
          3475                3480                3485            
  Ser Val Pro Cys Trp Gln Phe Ile Ser Trp Ile Ser His Met Val Ala
      3490                3495                3500                
  Leu Leu Asp Lys Asp Gln Ala Val Ala Val Gln His Ser Val Glu Glu
  3505                3510                3515                3520
  Ile Thr Asp Asn Tyr Pro Gln Ala Ile Val Tyr Pro Phe Ile Ile Ser
                  3525                3530                3535    
  Ser Glu Ser Tyr Ser Phe Lys Asp Thr Ser Thr Gly His Lys Asn Lys
              3540                3545                3550        
  Glu Phe Val Ala Arg Ile Lys Ser Lys Leu Asp Gln Gly Gly Val Ile
          3555                3560                3565            
  Gln Asp Phe Ile Asn Ala Leu Asp Gln Leu Ser Asn Pro Glu Leu Leu
      3570                3575                3580                
  Phe Lys Asp Trp Ser Asn Asp Val Arg Ala Glu Leu Ala Lys Thr Pro
  3585                3590                3595                3600
  Val Asn Lys Lys Asn Ile Glu Lys Met Tyr Glu Arg Met Tyr Ala Ala
                  3605                3610                3615    
  Leu Gly Asp Pro Lys Ala Pro Gly Leu Gly Ala Phe Arg Arg Lys Phe
              3620                3625                3630        
  Ile Gln Thr Phe Gly Lys Glu Phe Asp Lys His Phe Gly Lys Gly Gly
          3635                3640                3645            
  Ser Lys Leu Leu Arg Met Lys Leu Ser Asp Phe Asn Asp Ile Thr Asn
      3650                3655                3660                
  Met Leu Leu Leu Lys Met Asn Lys Asp Ser Lys Pro Pro Gly Asn Leu
  3665                3670                3675                3680
  Lys Glu Cys Ser Pro Trp Met Ser Asp Phe Lys Val Glu Phe Leu Arg
                  3685                3690                3695    
  Asn Glu Leu Glu Ile Pro Gly Gln Tyr Asp Gly Arg Gly Lys Pro Leu
              3700                3705                3710        
  Pro Glu Tyr His Val Arg Ile Ala Gly Phe Asp Glu Arg Val Thr Val
          3715                3720                3725            
  Met Ala Ser Leu Arg Arg Pro Lys Arg Ile Ile Ile Arg Gly His Asp
      3730                3735                3740                
  Glu Arg Glu His Pro Phe Leu Val Lys Gly Gly Glu Asp Leu Arg Gln
  3745                3750                3755                3760
  Asp Gln Arg Val Glu Gln Leu Phe Gln Val Met Asn Gly Ile Leu Ala
                  3765                3770                3775    
  Gln Asp Ser Ala Cys Ser Gln Arg Ala Leu Gln Leu Arg Thr Tyr Ser
              3780                3785                3790        
  Val Val Pro Met Thr Ser Arg Leu Gly Leu Ile Glu Trp Leu Glu Asn
          3795                3800                3805            
  Thr Val Thr Leu Lys Asp Leu Leu Leu Asn Thr Met Ser Gln Glu Glu
      3810                3815                3820                
  Lys Ala Ala Tyr Leu Ser Asp Pro Arg Ala Pro Pro Cys Glu Tyr Lys
  3825                3830                3835                3840
  Asp Trp Leu Thr Lys Met Ser Gly Lys His Asp Val Gly Ala Tyr Met
                  3845                3850                3855    
  Leu Met Tyr Lys Gly Ala Asn Arg Thr Glu Thr Val Thr Ser Phe Arg
              3860                3865                3870        
  Lys Arg Glu Ser Lys Val Pro Ala Asp Leu Leu Lys Arg Ala Phe Val
          3875                3880                3885            
  Arg Met Ser Thr Ser Pro Glu Ala Phe Leu Ala Leu Arg Ser His Phe
      3890                3895                3900                
  Ala Ser Ser His Ala Leu Ile Cys Ile Ser His Trp Ile Leu Gly Ile
  3905                3910                3915                3920
  Gly Asp Arg His Leu Asn Asn Phe Met Val Ala Met Glu Thr Gly Gly
                  3925                3930                3935    
  Val Ile Gly Ile Asp Phe Gly His Ala Phe Gly Ser Ala Thr Gln Phe
              3940                3945                3950        
  Leu Pro Val Pro Glu Leu Met Pro Phe Arg Leu Thr Arg Gln Phe Ile
          3955                3960                3965            
  Asn Leu Met Leu Pro Met Lys Glu Thr Gly Leu Met Tyr Ser Ile Met
      3970                3975                3980                
  Val His Ala Leu Arg Ala Phe Arg Ser Asp Pro Gly Leu Leu Thr Asn
  3985                3990                3995                4000
  Thr Met Asp Val Phe Val Lys Glu Pro Ser Phe Asp Trp Lys Asn Phe
                  4005                4010                4015    
  Glu Gln Lys Met Leu Lys Lys Gly Gly Ser Trp Ile Gln Glu Ile Asn
              4020                4025                4030        
  Val Ala Glu Lys Asn Trp Tyr Pro Arg Gln Lys Ile Cys Tyr Ala Lys
          4035                4040                4045            
  Arg Lys Leu Ala Gly Ala Asn Pro Ala Val Ile Thr Cys Asp Glu Leu
      4050                4055                4060                
  Leu Leu Gly His Glu Lys Ala Pro Ala Phe Arg Asp Tyr Val Ala Val
  4065                4070                4075                4080
  Ala Arg Gly Ser Lys Asp His Asn Ile Arg Ala Gln Glu Pro Glu Ser
                  4085                4090                4095    
  Gly Leu Ser Glu Glu Thr Gln Val Lys Cys Leu Met Asp Gln Ala Thr
              4100                4105                4110        
  Asp Pro Asn Ile Leu Gly Arg Thr Trp Glu Gly Trp Glu Pro Trp Met
          4115                4120                4125            
  
  
  
  
  <210> 2
  <211> 13509
  <212> DNA
  <213> Homo sapiens
  
  <400> 2
  ggggcatttc cgggtccggg ccgagcgggc gcacgcgcgg gagcgggact cggcggcatg 60
  gcgggctccg gagccggtgt gcgttgctcc ctgctgcggc tgcaggagac cttgtccgct 120
  gcggaccgct gcggtgctgc cctggccggt catcaactga tccgcggcct ggggcaggaa 180
  tgcgtcctga gcagcagccc cgcggtgctg gcattacaga catctttagt tttttccaga 240
  gatttcggtt tgcttgtatt tgtccggaag tcactcaaca gtattgaatt tcgtgaatgt 300
  agagaagaaa tcctaaagtt tttatgtatt ttcttagaaa aaatgggcca gaagatcgca 360
  ccttactctg ttgaaattaa gaacacttgt accagtgttt atacaaaaga tagagctgct 420
  aaatgtaaaa ttccagccct ggaccttctt attaagttac ttcagacttt tagaagttct 480
  agactcatgg atgaatttaa aattggagaa ttatttagta aattctatgg agaacttgca 540
  ttgaaaaaaa aaataccaga tacagtttta gaaaaagtat atgagctcct aggattattg 600
  ggtgaagttc atcctagtga gatgataaat aatgcagaaa acctgttccg cgcttttctg 660
  ggtgaactta agacccagat gacatcagca gtaagagagc ccaaactacc tgttctggca 720
  ggatgtctga aggggttgtc ctcacttctg tgcaacttca ctaagtccat ggaagaagat 780
  ccccagactt caagggagat ttttaatttt gtactaaagg caattcgtcc tcagattgat 840
  ctgaagagat atgctgtgcc ctcagctggc ttgcgcctat ttgccctgca tgcatctcag 900
  tttagcacct gccttctgga caactacgtg tctctatttg aagtcttgtt aaagtggtgt 960
  gcccacacaa atgtagaatt gaaaaaagct gcactttcag ccctggaatc ctttctgaaa 1020
  caggtttcta atatggtggc gaaaaatgca gaaatgcata aaaataaact gcagtacttt 1080
  atggagcagt tttatggaat catcagaaat gtggattcga acaacaagga gttatctatt 1140
  gctatccgtg gatatggact ttttgcagga ccgtgcaagg ttataaacgc aaaagatgtt 1200
  gacttcatgt acgttgagct cattcagcgc tgcaagcaga tgttcctcac ccagacagac 1260
  actggtgacg accgtgttta tcagatgcca agcttcctcc agtctgttgc aagcgtcttg 1320
  ctgtaccttg acacagttcc tgaggtgtat actccagttc tggagcacct cgtggtgatg 1380
  cagatagaca gtttcccaca gtacagtcca aaaatgcagc tggtgtgttg cagagccata 1440
  gtgaaggtgt tcctagcttt ggcagcaaaa gggccagttc tcaggaattg cattagtact 1500
  gtggtgcatc agggtttaat cagaatatgt tctaaaccag tggtccttcc aaagggccct 1560
  gagtctgaat ctgaagacca ccgtgcttca ggggaagtca gaactggcaa atggaaggtg 1620
  cccacataca aagactacgt ggatctcttc agacatctcc tgagctctga ccagatgatg 1680
  gattctattt tagcagatga agcatttttc tctgtgaatt cctccagtga aagtctgaat 1740
  catttacttt atgatgaatt tgtaaaatcc gttttgaaga ttgttgagaa attggatctt 1800
  acacttgaaa tacagactgt tggggaacaa gagaatggag atgaggcgcc tggtgtttgg 1860
  atgatcccaa cttcagatcc agcggctaac ttgcatccag ctaaacctaa agatttttcg 1920
  gctttcatta acctggtgga attttgcaga gagattctcc ctgagaaaca agcagaattt 1980
  tttgaaccat gggtgtactc attttcatat gaattaattt tgcaatctac aaggttgccc 2040
  ctcatcagtg gtttctacaa attgctttct attacagtaa gaaatgccaa gaaaataaaa 2100
  tatttcgagg gagttagtcc aaagagtctg aaacactctc ctgaagaccc agaaaagtat 2160
  tcttgctttg ctttatttgt gaaatttggc aaagaggtgg cagttaaaat gaagcagtac 2220
  aaagatgaac ttttggcctc ttgtttgacc tttcttctgt ccttgccaca caacatcatt 2280
  gaactcgatg ttagagccta cgttcctgca ctgcagatgg ctttcaaact gggcctgagc 2340
  tataccccct tggcagaagt aggcctgaat gctctagaag aatggtcaat ttatattgac 2400
  agacatgtaa tgcagcctta ttacaaagac attctcccct gcctggatgg atacctgaag 2460
  acttcagcct tgtcagatga gaccaagaat aactgggaag tgtcagctct ttctcgggct 2520
  gcccagaaag gatttaataa agtggtgtta aagcatctga agaagacaaa gaacctttca 2580
  tcaaacgaag caatatcctt agaagaaata agaattagag tagtacaaat gcttggatct 2640
  ctaggaggac aaataaacaa aaatcttctg acagtcacgt cctcagatga gatgatgaag 2700
  agctatgtgg cctgggacag agagaagcgg ctgagctttg cagtgccctt tagagagatg 2760
  aaacctgtca ttttcctgga tgtgttcctg cctcgagtca cagaattagc gctcacagcc 2820
  agtgacagac aaactaaagt tgcagcctgt gaacttttac atagcatggt tatgtttatg 2880
  ttgggcaaag ccacgcagat gccagaaggg ggacagggag ccccacccat gtaccagctc 2940
  tataagcgga cgtttcctgt gctgcttcga cttgcgtgtg atgttgatca ggtgacaagg 3000
  caactgtatg agccactagt tatgcagctg attcactggt tcactaacaa caagaaattt 3060
  gaaagtcagg atactgttgc cttactagaa gctatattgg atggaattgt ggaccctgtt 3120
  gacagtactt taagagattt ttgtggtcgg tgtattcgag aattccttaa atggtccatt 3180
  aagcaaataa caccacagca gcaggagaag agtccagtaa acaccaaatc gcttttcaag 3240
  cgactttata gccttgcgct tcaccccaat gctttcaaga ggctgggagc atcacttgcc 3300
  tttaataata tctacaggga attcagggaa gaagagtctc tggtggaaca gtttgtgttt 3360
  gaagccttgg tgatatacat ggagagtctg gccttagcac atgcagatga gaagtcctta 3420
  ggtacaattc aacagtgttg tgatgccatt gatcacctat gccgcatcat tgaaaagaag 3480
  catgtttctt taaataaagc aaagaaacga cgtttgccgc gaggatttcc accttccgca 3540
  tcattgtgtt tattggatct ggtcaagtgg cttttagctc attgtgggag gccccagaca 3600
  gaatgtcgac acaaatccat tgaactcttt tataaattcg ttcctttatt gccaggcaac 3660
  agatccccta atttgtggct gaaagatgtt ctcaaggaag aaggtgtctc ttttctcatc 3720
  aacacctttg aggggggtgg ctgtggccag ccctcgggca tcctggccca gcccaccctc 3780
  ttgtaccttc gggggccatt cagcctgcag gccacgctat gctggctgga cctgctcctg 3840
  gccgcgttgg agtgctacaa cacgttcatt ggcgagagaa ctgtaggagc gctccaggtc 3900
  ctaggtactg aagcccagtc ttcacttttg aaagcagtgg ctttcttctt agaaagcatt 3960
  gccatgcatg acattatagc agcagaaaag tgctttggca ctggggcagc aggtaacaga 4020
  acaagcccac aagagggaga aaggtacaac tacagcaaat gcaccgttgt ggtccggatt 4080
  atggagttta ccacgactct gctaaacacc tccccggaag gatggaagct cctgaagaag 4140
  gacttgtgta atacacacct gatgagagtc ctggtgcaga cgctgtgtga gcccgcaagc 4200
  ataggtttca acatcggaga cgtccaggtt atggctcatc ttcctgatgt ttgtgtgaat 4260
  ctgatgaaag ctctaaagat gtccccatac aaagatatcc tagagaccca tctgagagag 4320
  aaaataacag cacagagcat tgaggagctt tgtgccgtca acttgtatgg ccctgacgcg 4380
  caagtggaca ggagcaggct ggctgctgtt gtgtctgcct gtaaacagct tcacagagct 4440
  gggcttctgc ataatatatt accgtctcag tccacagatt tgcatcattc tgttggcaca 4500
  gaacttcttt ccctggttta taaaggcatt gcccctggag atgagagaca gtgtctgcct 4560
  tctctagacc tcagttgtaa gcagctggcc agcggacttc tggagttagc ctttgctttt 4620
  ggaggactgt gtgagcgcct tgtgagtctt ctcctgaacc cagcggtgct gtccacggcg 4680
  tccttgggca gctcacaggg cagcgtcatc cacttctccc atggggagta tttctatagc 4740
  ttgttctcag aaacgatcaa cacggaatta ttgaaaaatc tggatcttgc tgtattggag 4800
  ctcatgcagt cttcagtgga taataccaaa atggtgagtg ccgttttgaa cggcatgtta 4860
  gaccagagct tcagggagcg agcaaaccag aaacaccaag gactgaaact tgcgactaca 4920
  attctgcaac actggaagaa gtgtgattca tggtgggcca aagattcccc tctcgaaact 4980
  aaaatggcag tgctggcctt actggcaaaa attttacaga ttgattcatc tgtatctttt 5040
  aatacaagtc atggttcatt ccctgaagtc tttacaacat atattagtct acttgctgac 5100
  acaaagctgg atctacattt aaagggccaa gctgtcactc ttcttccatt cttcaccagc 5160
  ctcactggag gcagtctgga ggaacttaga cgtgttctgg agcagctcat cgttgctcac 5220
  ttccccatgc agtccaggga atttcctcca ggaactccgc ggttcaataa ttatgtggac 5280
  tgcatgaaaa agtttctaga tgcattggaa ttatctcaaa gccctatgtt gttggaattg 5340
  atgacagaag ttctttgtcg ggaacagcag catgtcatgg aagaattatt tcaatccagt 5400
  ttcaggagga ttgccagaag gggttcatgt gtcacacaag taggccttct ggaaagcgtg 5460
  tatgaaatgt tcaggaagga tgacccccgc ctaagtttca cacgccagtc ctttgtggac 5520
  cgctccctcc tcactctgct gtggcactgt agcctggatg ctttgagaga attcttcagc 5580
  acaattgtgg tggatgccat tgatgtgttg aagtccaggt ttacaaagct aaatgaatct 5640
  acctttgata ctcaaatcac caagaagatg ggctactata agattctaga cgtgatgtat 5700
  tctcgccttc ccaaagatga tgttcatgct aaggaatcaa aaattaatca agttttccat 5760
  ggctcgtgta ttacagaagg aaatgaactt acaaagacat tgattaaatt gtgctacgat 5820
  gcatttacag agaacatggc aggagagaat cagctgctgg agaggagaag actttaccat 5880
  tgtgcagcat acaactgcgc catatctgtc atctgctgtg tcttcaatga gttaaaattt 5940
  taccaaggtt ttctgtttag tgaaaaacca gaaaagaact tgcttatttt tgaaaatctg 6000
  atcgacctga agcgccgcta taattttcct gtagaagttg aggttcctat ggaaagaaag 6060
  aaaaagtaca ttgaaattag gaaagaagcc agagaagcag caaatgggga ttcagatggt 6120
  ccttcctata tgtcttccct gtcatatttg gcagacagta ccctgagtga ggaaatgagt 6180
  caatttgatt tctcaaccgg agttcagagc tattcataca gctcccaaga ccctagacct 6240
  gccactggtc gttttcggag acgggagcag cgggacccca cggtgcatga tgatgtgctg 6300
  gagctggaga tggacgagct caatcggcat gagtgcatgg cgcccctgac ggccctggtc 6360
  aagcacatgc acagaagcct gggcccgcct caaggagaag aggattcagt gccaagagat 6420
  cttccttctt ggatgaaatt cctccatggc aaactgggaa atccaatagt accattaaat 6480
  atccgtctct tcttagccaa gcttgttatt aatacagaag aggtctttcg cccttacgcg 6540
  aagcactggc ttagcccctt gctgcagctg gctgcttctg aaaacaatgg aggagaagga 6600
  attcactaca tggtggttga gatagtggcc actattcttt catggacagg cttggccact 6660
  ccaacagggg tccctaaaga tgaagtgtta gcaaatcgat tgcttaattt cctaatgaaa 6720
  catgtctttc atccaaaaag agctgtgttt agacacaacc ttgaaattat aaagaccctt 6780
  gtcgagtgct ggaaggattg tttatccatc ccttataggt taatatttga aaagttttcc 6840
  ggtaaagatc ctaattctaa agacaactca gtagggattc aattgctagg catcgtgatg 6900
  gccaatgacc tgcctcccta tgacccacag tgtggcatcc agagtagcga atacttccag 6960
  gctttggtga ataatatgtc ctttgtaaga tataaagaag tgtatgccgc tgcagcagaa 7020
  gttctaggac ttatacttcg atatgttatg gagagaaaaa acatactgga ggagtctctg 7080
  tgtgaactgg ttgcgaaaca attgaagcaa catcagaata ctatggagga caagtttatt 7140
  gtgtgcttga acaaagtgac caagagcttc cctcctcttg cagacaggtt catgaatgct 7200
  gtgttctttc tgctgccaaa atttcatgga gtgttgaaaa cactctgtct ggaggtggta 7260
  ctttgtcgtg tggagggaat gacagagctg tacttccagt taaagagcaa ggacttcgtt 7320
  caagtcatga gacatagaga tgatgaaaga caaaaagtat gtttggacat aatttataag 7380
  atgatgccaa agttaaaacc agtagaactc cgagaacttc tgaaccccgt tgtggaattc 7440
  gtttcccatc cttctacaac atgtagggaa caaatgtata atattctcat gtggattcat 7500
  gataattaca gagatccaga aagtgagaca gataatgact cccaggaaat atttaagttg 7560
  gcaaaagatg tgctgattca aggattgatc gatgagaacc ctggacttca attaattatt 7620
  cgaaatttct ggagccatga aactaggtta ccttcaaata ccttggaccg gttgctggca 7680
  ctaaattcct tatattctcc taagatagaa gtgcactttt taagtttagc aacaaatttt 7740
  ctgctcgaaa tgaccagcat gagcccagat tatccaaacc ccatgttcga gcatcctctg 7800
  tcagaatgcg aatttcagga atataccatt gattctgatt ggcgtttccg aagtactgtt 7860
  ctcactccga tgtttgtgga gacccaggcc tcccagggca ctctccagac ccgtacccag 7920
  gaagggtccc tctcagctcg ctggccagtg gcagggcaga taagggccac ccagcagcag 7980
  catgacttca cactgacaca gactgcagat ggaagaagct catttgattg gctgaccggg 8040
  agcagcactg acccgctggt cgaccacacc agtccctcat ctgactcctt gctgtttgcc 8100
  cacaagagga gtgaaaggtt acagagagca cccttgaagt cagtggggcc tgattttggg 8160
  aaaaaaaggc tgggccttcc aggggacgag gtggataaca aagtgaaagg tgcggccggc 8220
  cggacggacc tactacgact gcgcagacgg tttatgaggg accaggagaa gctcagtttg 8280
  atgtatgcca gaaaaggcgt tgctgagcaa aaacgagaga aggaaatcaa gagtgagtta 8340
  aaaatgaagc aggatgccca ggtcgttctg tacagaagct accggcacgg agaccttcct 8400
  gacattcaga tcaagcacag cagcctcatc accccgttac aggccgtggc ccagagggac 8460
  ccaataattg caaaacagct ctttagcagc ttgttttctg gaattttgaa agagatggat 8520
  aaatttaaga cactgtctga aaaaaacaac atcactcaaa agttgcttca agacttcaat 8580
  cgttttctta ataccacctt ctctttcttt ccaccctttg tctcttgtat tcaggacatt 8640
  agctgtcagc acgcagccct gctgagcctc gacccagcgg ctgttagcgc tggttgcctg 8700
  gccagcctac agcagcccgt gggcatccgc ctgctagagg aggctctgct ccgcctgctg 8760
  cctgctgagc tgcctgccaa gcgagtccgt gggaaggccc gcctccctcc tgatgtcctc 8820
  agatgggtgg agcttgctaa gctgtataga tcaattggag aatacgacgt cctccgtggg 8880
  atttttacca gtgagatagg aacaaagcaa atcactcaga gtgcattatt agcagaagcc 8940
  agaagtgatt attctgaagc tgctaagcag tatgatgagg ctctcaataa acaagactgg 9000
  gtagatggtg agcccacaga agccgagaag gatttttggg aacttgcatc ccttgactgt 9060
  tacaaccacc ttgctgagtg gaaatcactt gaatactgtt ctacagccag tatagacagt 9120
  gagaaccccc cagacctaaa taaaatctgg agtgaaccat tttatcagga aacatatcta 9180
  ccttacatga tccgcagcaa gctgaagctg ctgctccagg gagaggctga ccagtccctg 9240
  ctgacattta ttgacaaagc tatgcacggg gagctccaga aggcgattct agagcttcat 9300
  tacagtcaag agctgagtct gctttacctc ctgcaagatg atgttgacag agccaaatat 9360
  tacattcaaa atggcattca gagttttatg cagaattatt ctagtattga tgtcctctta 9420
  caccaaagta gactcaccaa attgcagtct gtacaggctt taacagaaat tcaggagttc 9480
  atcagcttta taagcaaaca aggcaattta tcatctcaag ttccccttaa gagacttctg 9540
  aacacctgga caaacagata tccagatgct aaaatggacc caatgaacat ctgggatgac 9600
  atcatcacaa atcgatgttt ctttctcagc aaaatagagg agaagcttac ccctcttcca 9660
  gaagataata gtatgaatgt ggatcaagat ggagacccca gtgacaggat ggaagtgcaa 9720
  gagcaggaag aagatatcag ctccctgatc aggagttgca agttttccat gaaaatgaag 9780
  atgatagaca gtgcccggaa gcagaacaat ttctcacttg ctatgaaact actgaaggag 9840
  ctgcataaag agtcaaaaac cagagacgat tggctggtga gctgggtgca gagctactgc 9900
  cgcctgagcc actgccggag ccggtcccag ggctgctctg agcaggtgct cactgtgctg 9960
  aaaacagtct ctttgttgga tgagaacaac gtgtcaagct acttaagcaa aaatattctg 10020
  gctttccgtg accagaacat tctcttgggt acaacttaca ggatcatagc gaatgctctc 10080
  agcagtgagc cagcctgcct tgctgaaatc gaggaggaca aggctagaag aatcttagag 10140
  ctttctggat ccagttcaga ggattcagag aaggtgatcg cgggtctgta ccagagagca 10200
  ttccagcacc tctctgaggc tgtgcaggcg gctgaggagg aggcccagcc tccctcctgg 10260
  agctgtgggc ctgcagctgg ggtgattgat gcttacatga cgctggcaga tttctgtgac 10320
  caacagctgc gcaaggagga agagaatgca tcagttattg attctgcaga actgcaggcg 10380
  tatccagcac ttgtggtgga gaaaatgttg aaagctttaa aattaaattc caatgaagcc 10440
  agattgaagt ttcctagatt acttcagatt atagaacggt atccagagga gactttgagc 10500
  ctcatgacaa aagagatctc ttccgttccc tgctggcagt tcatcagctg gatcagccac 10560
  atggtggcct tactggacaa agaccaagcc gttgctgttc agcactctgt ggaagaaatc 10620
  actgataact acccgcaggc tattgtttat cccttcatca taagcagcga aagctattcc 10680
  ttcaaggata cttctactgg tcataagaat aaggagtttg tggcaaggat taaaagtaag 10740
  ttggatcaag gaggagtgat tcaagatttt attaatgcct tagatcagct ctctaatcct 10800
  gaactgctct ttaaggattg gagcaatgat gtaagagctg aactagcaaa aacccctgta 10860
  aataaaaaaa acattgaaaa aatgtatgaa agaatgtatg cagccttggg tgacccaaag 10920
  gctccaggcc tgggggcctt tagaaggaag tttattcaga cttttggaaa agaatttgat 10980
  aaacattttg ggaaaggagg ttctaaacta ctgagaatga agctcagtga cttcaacgac 11040
  attaccaaca tgctactttt aaaaatgaac aaagactcaa agccccctgg gaatctgaaa 11100
  gaatgttcac cctggatgag cgacttcaaa gtggagttcc tgagaaatga gctggagatt 11160
  cccggtcagt atgacggtag gggaaagcca ttgccagagt accacgtgcg aatcgccggg 11220
  tttgatgagc gggtgacagt catggcgtct ctgcgaaggc ccaagcgcat catcatccgt 11280
  ggccatgacg agagggaaca ccctttcctg gtgaagggtg gcgaggacct gcggcaggac 11340
  cagcgcgtgg agcagctctt ccaggtcatg aatgggatcc tggcccaaga ctccgcctgc 11400
  agccagaggg ccctgcagct gaggacctat agcgttgtgc ccatgacctc caggttagga 11460
  ttaattgagt ggcttgaaaa tactgttacc ttgaaggacc ttcttttgaa caccatgtcc 11520
  caagaggaga aggcggctta cctgagtgat cccagggcac cgccgtgtga atataaagat 11580
  tggctgacaa aaatgtcagg aaaacatgat gttggagctt acatgctaat gtataagggc 11640
  gctaatcgta ctgaaacagt cacgtctttt agaaaacgag aaagtaaagt gcctgctgat 11700
  ctcttaaagc gggccttcgt gaggatgagt acaagccctg aggctttcct ggcgctccgc 11760
  tcccacttcg ccagctctca cgctctgata tgcatcagcc actggatcct cgggattgga 11820
  gacagacatc tgaacaactt tatggtggcc atggagactg gcggcgtgat cgggatcgac 11880
  tttgggcatg cgtttggatc cgctacacag tttctgccag tccctgagtt gatgcctttt 11940
  cggctaactc gccagtttat caatctgatg ttaccaatga aagaaacggg ccttatgtac 12000
  agcatcatgg tacacgcact ccgggccttc cgctcagacc ctggcctgct caccaacacc 12060
  atggatgtgt ttgtcaagga gccctccttt gattggaaaa attttgaaca gaaaatgctg 12120
  aaaaaaggag ggtcatggat tcaagaaata aatgttgctg aaaaaaattg gtacccccga 12180
  cagaaaatat gttacgctaa gagaaagtta gcaggtgcca atccagcagt cattacttgt 12240
  gatgagctac tcctgggtca tgagaaggcc cctgccttca gagactatgt ggctgtggca 12300
  cgaggaagca aagatcacaa cattcgtgcc caagaaccag agagtgggct ttcagaagag 12360
  actcaagtga agtgcctgat ggaccaggca acagacccca acatccttgg cagaacctgg 12420
  gaaggatggg agccctggat gtgaggtctg tgggagtctg cagatagaaa gcattacatt 12480
  gtttaaagaa tctactatac tttggttggc agcattccat gagctgattt tcctgaaaca 12540
  ctaaagagaa atgtcttttg tgctacagtt tcgtagcatg agtttaaatc aagattatga 12600
  tgagtaaatg tgtatgggtt aaatcaaaga taaggttata gtaacatcaa agattaggtg 12660
  aggtttatag aaagatagat atccaggctt accaaagtat taagtcaaga atataatatg 12720
  tgatcagctt tcaaagcatt tacaagtgct gcaagttagt gaaacagctg tctccgtaaa 12780
  tggaggaaat gtggggaagc cttggaatgc ccttctggtt ctggcacatt ggaaagcaca 12840
  ctcagaaggc ttcatcacca agattttggg agagtaaagc taagtatagt tgatgtaaca 12900
  ttgtagaagc agcataggaa caataagaac aataggtaaa gctataatta tggcttatat 12960
  ttagaaatga ctgcatttga tattttagga tatttttcta ggttttttcc tttcatttta 13020
  ttctcttcta gttttgacat tttatgatag atttgctctc tagaaggaaa cgtctttatt 13080
  taggagggca aaaattttgg tcatagcatt cacttttgct attccaatct acaactggaa 13140
  gatacataaa agtgctttgc attgaatttg ggataacttc aaaaatccca tggttgttgt 13200
  tagggatagt actaagcatt tcagttccag gagaataaaa gaaattccta tttgaaatga 13260
  attcctcatt tggaggaaaa aaagcatgca ttctagcaca acaagatgaa attatggaat 13320
  acaaaagtgg ctccttccca tgtgcagtcc ctgtcccccc ccgccagtcc tccacaccca 13380
  aactgtttct gattggcttt tagctttttg ttgttttttt ttttccttct aacacttgta 13440
  tttggaggct cttctgtgat tttgagaagt atactcttga gtgtttaata aagttttttt 13500
  ccaaaagta                                                         13509
  
  
  
  <210> 3
  <211> 1689
  <212> PRT
  <213> Homo sapiens
  
  <400> 3
  Met Ala Gly Ser Gly Ala Gly Val Arg Cys Ser Leu Leu Arg Leu Gln
   1               5                  10                  15      
  Glu Thr Leu Ser Ala Ala Asp Arg Cys Gly Ala Ala Leu Ala Gly His
              20                  25                  30          
  Gln Leu Ile Arg Gly Leu Gly Gln Glu Cys Val Leu Ser Ser Ser Pro
          35                  40                  45              
  Ala Val Leu Ala Leu Gln Thr Ser Leu Val Phe Ser Arg Asp Phe Gly
      50                  55                  60                  
  Leu Leu Val Phe Val Arg Lys Ser Leu Asn Ser Ile Glu Phe Arg Glu
  65                  70                  75                  80  
  
  Cys Arg Glu Glu Ile Leu Lys Phe Leu Cys Ile Phe Leu Glu Lys Met
                  85                  90                  95      
  Gly Gln Lys Ile Ala Pro Tyr Ser Val Glu Ile Lys Asn Thr Cys Thr
              100                 105                 110         
  Ser Val Tyr Thr Lys Asp Arg Ala Ala Lys Cys Lys Ile Pro Ala Leu
          115                 120                 125             
  Asp Leu Leu Ile Lys Leu Leu Gln Thr Phe Arg Ser Ser Arg Leu Met
      130                 135                 140                 
  Asp Glu Phe Lys Ile Gly Glu Leu Phe Ser Lys Phe Tyr Gly Glu Leu
  145                 150                 155                 160 
  Ala Leu Lys Lys Lys Ile Pro Asp Thr Val Leu Glu Lys Val Tyr Glu
                  165                 170                 175     
  Leu Leu Gly Leu Leu Gly Glu Val His Pro Ser Glu Met Ile Asn Asn
              180                 185                 190         
  Ala Glu Asn Leu Phe Arg Ala Phe Leu Gly Glu Leu Lys Thr Gln Met
          195                 200                 205             
  Thr Ser Ala Val Arg Glu Pro Lys Leu Pro Val Leu Ala Gly Cys Leu
      210                 215                 220                 
  Lys Gly Leu Ser Ser Leu Leu Cys Asn Phe Thr Lys Ser Met Glu Glu
  225                 230                 235                 240 
  Asp Pro Gln Thr Ser Arg Glu Ile Phe Asn Phe Val Leu Lys Ala Ile
                  245                 250                 255     
  Arg Pro Gln Ile Asp Leu Lys Arg Tyr Ala Val Pro Ser Ala Gly Leu
              260                 265                 270         
  Arg Leu Phe Ala Leu His Ala Ser Gln Phe Ser Thr Cys Leu Leu Asp
          275                 280                 285             
  Asn Tyr Val Ser Leu Phe Glu Val Leu Leu Lys Trp Cys Ala His Thr
      290                 295                 300                 
  Asn Val Glu Leu Lys Lys Ala Ala Leu Ser Ala Leu Glu Ser Phe Leu
  305                 310                 315                 320 
  Lys Gln Val Ser Asn Met Val Ala Lys Asn Ala Glu Met His Lys Asn
                  325                 330                 335     
  Lys Leu Gln Tyr Phe Met Glu Gln Phe Tyr Gly Ile Ile Arg Asn Val
              340                 345                 350         
  Asp Ser Asn Asn Lys Glu Leu Ser Ile Ala Ile Arg Gly Tyr Gly Leu
          355                 360                 365             
  Phe Ala Gly Pro Cys Lys Val Ile Asn Ala Lys Asp Val Asp Phe Met
      370                 375                 380                 
  Tyr Val Glu Leu Ile Gln Arg Cys Lys Gln Met Phe Leu Thr Gln Thr
  385                 390                 395                 400 
  Asp Thr Gly Asp Asp Arg Val Tyr Gln Met Pro Ser Phe Leu Gln Ser
                  405                 410                 415     
  Val Ala Ser Val Leu Leu Tyr Leu Asp Thr Val Pro Glu Val Tyr Thr
              420                 425                 430         
  Pro Val Leu Glu His Leu Val Val Met Gln Ile Asp Ser Phe Pro Gln
          435                 440                 445             
  Tyr Ser Pro Lys Met Gln Leu Val Cys Cys Arg Ala Ile Val Lys Val
      450                 455                 460                 
  Phe Leu Ala Leu Ala Ala Lys Gly Pro Val Leu Arg Asn Cys Ile Ser
  465                 470                 475                 480 
  Thr Val Val His Gln Gly Leu Ile Arg Ile Cys Ser Lys Pro Val Val
                  485                 490                 495     
  Leu Pro Lys Gly Pro Glu Ser Glu Ser Glu Asp His Arg Ala Ser Gly
              500                 505                 510         
  Glu Val Arg Thr Gly Lys Trp Lys Val Pro Thr Tyr Lys Asp Tyr Val
          515                 520                 525             
  Asp Leu Phe Arg His Leu Leu Ser Ser Asp Gln Met Met Asp Ser Ile
      530                 535                 540                 
  Leu Ala Asp Glu Ala Phe Phe Ser Val Asn Ser Ser Ser Glu Ser Leu
  545                 550                 555                 560 
  Asn His Leu Leu Tyr Asp Glu Phe Val Lys Ser Val Leu Lys Ile Val
                  565                 570                 575     
  Glu Lys Leu Asp Leu Thr Leu Glu Ile Gln Thr Val Gly Glu Gln Glu
              580                 585                 590         
  Asn Gly Asp Glu Ala Pro Gly Val Trp Met Ile Pro Thr Ser Asp Pro
          595                 600                 605             
  Ala Ala Asn Leu His Pro Ala Lys Pro Lys Asp Phe Ser Ala Phe Ile
      610                 615                 620                 
  Asn Leu Val Glu Phe Cys Arg Glu Ile Leu Pro Glu Lys Gln Ala Glu
  625                 630                 635                 640 
  Phe Phe Glu Pro Trp Val Tyr Ser Phe Ser Tyr Glu Leu Ile Leu Gln
                  645                 650                 655     
  Ser Thr Arg Leu Pro Leu Ile Ser Gly Phe Tyr Lys Leu Leu Ser Ile
              660                 665                 670         
  Thr Val Arg Asn Ala Lys Lys Ile Lys Tyr Phe Glu Gly Val Ser Pro
          675                 680                 685             
  Lys Ser Leu Lys His Ser Pro Glu Asp Pro Glu Lys Tyr Ser Cys Phe
      690                 695                 700                 
  Ala Leu Phe Val Lys Phe Gly Lys Glu Val Ala Val Lys Met Lys Gln
  705                 710                 715                 720 
  Tyr Lys Asp Glu Leu Leu Ala Ser Cys Leu Thr Phe Leu Leu Ser Leu
                  725                 730                 735     
  Pro His Asn Ile Ile Glu Leu Asp Val Arg Ala Tyr Val Pro Ala Leu
              740                 745                 750         
  Gln Met Ala Phe Lys Leu Gly Leu Ser Tyr Thr Pro Leu Ala Glu Val
          755                 760                 765             
  Gly Leu Asn Ala Leu Glu Glu Trp Ser Ile Tyr Ile Asp Arg His Val
      770                 775                 780                 
  Met Gln Pro Tyr Tyr Lys Asp Ile Leu Pro Cys Leu Asp Gly Tyr Leu
  785                 790                 795                 800 
  Lys Thr Ser Ala Leu Ser Asp Glu Thr Lys Asn Asn Trp Glu Val Ser
                  805                 810                 815     
  Ala Leu Ser Arg Ala Ala Gln Lys Gly Phe Asn Lys Val Val Leu Lys
              820                 825                 830         
  His Leu Lys Lys Thr Lys Asn Leu Ser Ser Asn Glu Ala Ile Ser Leu
          835                 840                 845             
  Glu Glu Ile Arg Ile Arg Val Val Gln Met Leu Gly Ser Leu Gly Gly
      850                 855                 860                 
  Gln Ile Asn Lys Asn Leu Leu Thr Val Thr Ser Ser Asp Glu Met Met
  865                 870                 875                 880 
  Lys Ser Tyr Val Ala Trp Asp Arg Glu Lys Arg Leu Ser Phe Ala Val
                  885                 890                 895     
  Pro Phe Arg Glu Met Lys Pro Val Ile Phe Leu Asp Val Phe Leu Pro
              900                 905                 910         
  Arg Val Thr Glu Leu Ala Leu Thr Ala Ser Asp Arg Gln Thr Lys Val
          915                 920                 925             
  Ala Ala Cys Glu Leu Leu His Ser Met Val Met Phe Met Leu Gly Lys
      930                 935                 940                 
  Ala Thr Gln Met Pro Glu Gly Gly Gln Gly Ala Pro Pro Met Tyr Gln
  945                 950                 955                 960 
  Leu Tyr Lys Arg Thr Phe Pro Val Leu Leu Arg Leu Ala Cys Asp Val
                  965                 970                 975     
  Asp Gln Val Thr Arg Gln Leu Tyr Glu Pro Leu Val Met Gln Leu Ile
              980                 985                 990         
  His Trp Phe Thr Asn Asn Lys Lys Phe Glu Ser Gln Asp Thr Val Ala
          995                 1000                1005            
  Leu Leu Glu Ala Ile Leu Asp Gly Ile Val Asp Pro Val Asp Ser Thr
      1010                1015                1020                
  Leu Arg Asp Phe Cys Gly Arg Cys Ile Arg Glu Phe Leu Lys Trp Ser
  1025                1030                1035                1040
  Ile Lys Gln Ile Thr Pro Gln Gln Gln Glu Lys Ser Pro Val Asn Thr
                  1045                1050                1055    
  Lys Ser Leu Phe Lys Arg Leu Tyr Ser Leu Ala Leu His Pro Asn Ala
              1060                1065                1070        
  Phe Lys Arg Leu Gly Ala Ser Leu Ala Phe Asn Asn Ile Tyr Arg Glu
          1075                1080                1085            
  Phe Arg Glu Glu Glu Ser Leu Val Glu Gln Phe Val Phe Glu Ala Leu
      1090                1095                1100                
  Val Ile Tyr Met Glu Ser Leu Ala Leu Ala His Ala Asp Glu Lys Ser
  1105                1110                1115                1120
  Leu Gly Thr Ile Gln Gln Cys Cys Asp Ala Ile Asp His Leu Cys Arg
                  1125                1130                1135    
  Ile Ile Glu Lys Lys His Val Ser Leu Asn Lys Ala Lys Lys Arg Arg
              1140                1145                1150        
  Leu Pro Arg Gly Phe Pro Pro Ser Ala Ser Leu Cys Leu Leu Asp Leu
          1155                1160                1165            
  Val Lys Trp Leu Leu Ala His Cys Gly Arg Pro Gln Thr Glu Cys Arg
      1170                1175                1180                
  His Lys Ser Ile Glu Leu Phe Tyr Lys Phe Val Pro Leu Leu Pro Gly
  1185                1190                1195                1200
  Asn Arg Ser Pro Asn Leu Trp Leu Lys Asp Val Leu Lys Glu Glu Gly
                  1205                1210                1215    
  Val Ser Phe Leu Ile Asn Thr Phe Glu Gly Gly Gly Cys Gly Gln Pro
              1220                1225                1230        
  Ser Gly Ile Leu Ala Gln Pro Thr Leu Leu Tyr Leu Arg Gly Pro Phe
          1235                1240                1245            
  Ser Leu Gln Ala Thr Leu Cys Trp Leu Asp Leu Leu Leu Ala Ala Leu
      1250                1255                1260                
  Glu Cys Tyr Asn Thr Phe Ile Gly Glu Arg Thr Val Gly Ala Leu Gln
  1265                1270                1275                1280
  Val Leu Gly Thr Glu Ala Gln Ser Ser Leu Leu Lys Ala Val Ala Phe
                  1285                1290                1295    
  Phe Leu Glu Ser Ile Ala Met His Asp Ile Ile Ala Ala Glu Lys Cys
              1300                1305                1310        
  Phe Gly Thr Gly Ala Ala Gly Asn Arg Thr Ser Pro Gln Glu Gly Glu
          1315                1320                1325            
  Arg Tyr Asn Tyr Ser Lys Cys Thr Val Val Val Arg Ile Met Glu Phe
      1330                1335                1340                
  Thr Thr Thr Leu Leu Asn Thr Ser Pro Glu Gly Trp Lys Leu Leu Lys
  1345                1350                1355                1360
  Lys Asp Leu Cys Asn Thr His Leu Met Arg Val Leu Val Gln Thr Leu
                  1365                1370                1375    
  Cys Glu Pro Ala Ser Ile Gly Phe Asn Ile Gly Asp Val Gln Val Met
              1380                1385                1390        
  Ala His Leu Pro Asp Val Cys Val Asn Leu Met Lys Ala Leu Lys Met
          1395                1400                1405            
  Ser Pro Tyr Lys Asp Ile Leu Glu Thr His Leu Arg Glu Lys Ile Thr
      1410                1415                1420                
  Ala Gln Ser Ile Glu Glu Leu Cys Ala Val Asn Leu Tyr Gly Pro Asp
  1425                1430                1435                1440
  Ala Gln Val Asp Arg Ser Arg Leu Ala Ala Val Val Ser Ala Cys Lys
                  1445                1450                1455    
  Gln Leu His Arg Ala Gly Leu Leu His Asn Ile Leu Pro Ser Gln Ser
              1460                1465                1470        
  Thr Asp Leu His His Ser Val Gly Thr Glu Leu Leu Ser Leu Val Tyr
          1475                1480                1485            
  Lys Gly Ile Ala Pro Gly Asp Glu Arg Gln Cys Leu Pro Ser Leu Asp
      1490                1495                1500                
  Leu Ser Cys Lys Gln Leu Ala Ser Gly Leu Leu Glu Leu Ala Phe Ala
  1505                1510                1515                1520
  Phe Gly Gly Leu Cys Glu Arg Leu Val Ser Leu Leu Leu Asn Pro Ala
                  1525                1530                1535    
  Val Leu Ser Thr Ala Ser Leu Gly Ser Ser Gln Gly Ser Val Ile His
              1540                1545                1550        
  Phe Ser His Gly Glu Tyr Phe Tyr Ser Leu Phe Ser Glu Thr Ile Asn
          1555                1560                1565            
  Thr Glu Leu Leu Lys Asn Leu Asp Leu Ala Val Leu Glu Leu Met Gln
      1570                1575                1580                
  Ser Ser Val Asp Asn Thr Lys Met Val Ser Ala Val Leu Asn Gly Met
  1585                1590                1595                1600
  Leu Asp Gln Ser Phe Arg Glu Arg Ala Asn Gln Lys His Gln Gly Leu
                  1605                1610                1615    
  Lys Leu Ala Thr Thr Ile Leu Gln His Trp Lys Lys Cys Asp Ser Trp
              1620                1625                1630        
  Trp Ala Lys Asp Ser Pro Leu Glu Thr Lys Met Ala Val Leu Ala Leu
          1635                1640                1645            
  Leu Ala Lys Ile Leu Gln Ile Asp Ser Ser Val Ser Phe Asn Thr Ser
      1650                1655                1660                
  His Gly Ser Phe Pro Glu Val Phe Thr Thr Tyr Ile Ser Leu Leu Ala
  1665                1670                1675                1680
  Asp Thr Lys Leu Asp Leu His Leu Lys
                  1685                
  
  
  <210> 4
  <211> 9
  <212> DNA
  <213> Artificial Sequence
  
  
  <220> 
  <223> A synthetic oligonucleotide
  
  <400> 4
  uucaagaga                                                         9
  
  <210> 5
  <211> 21
  <212> DNA
  <213> Artificial Sequence
  
  <220> 
  <223> A synthetic primer
  
  <400> 5
  ccgcaaggga aagatgaaag a                                           21
  
  <210> 6
  <211> 20
  <212> DNA
  <213> Artificial Sequence
  
  <220> 
  <223> A synthetic primer
  
  <400> 6
  tcgtttggtt tcggggtttc                                             20
  
  <210> 7
  <211> 24
  <212> DNA
  <213> Artificial Sequence
  
  <220> 
  <223> A synthetic primer
  
  <400> 7
  gccagcctct cctgatttta gtgt                                        24
  
  
  
  
  <210> 8
  <211> 24
  <212> DNA
  <213> Artificial Sequence
  
  <220> 
  <223> A synthetic primer
  
  <400> 8
  gggaacacaa aagacctctt ctgg                                        24
